| Pair Name | Pulsatilla saponin D, Paclitaxel | ||
| Phytochemical Name | Pulsatilla saponin D (PubChem CID: 11650910 ) | ||
| Anticancer drug Name | Paclitaxel (PubChem CID: 36314 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Pulsatilla saponin D, Paclitaxel | |||
| Disease Info | [ICD-11: 2C25.Z] | Lung cancer | Investigative | |
| Gene Regulation | Down-regulation | Expression | RAC3 | hsa5881 |
| In Vitro Model | NCI-H1299 | Lung large cell carcinoma | Homo sapiens (Human) | CVCL_0060 |
| A-549 | Lung adenocarcinoma | Homo sapiens (Human) | CVCL_0023 | |
| In Vivo Model | A total of 5×10⁶ A549-PR and NCI-H1299-PR cells were subcutaneously injected near the dorsal flanks of the mice. | |||
| Result | We found that treatment with paclitaxel combined with Pulsatilla saponin D, can overcome lung adenocarcinoma cell resistance to paclitaxel alone in cell culture and mouse xenograft models. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Pulsatilla saponin D regulates ras-related C3 botulinum toxin substrate 3 (RAC3) to overcome resistance to paclitaxel in lung adenocarcinoma cells. BMC Cancer. 2024 Jan 10;24(1):55. doi: 10.1186/s12885-024-11841-6. | Click |
